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Affymetrix Genechip DNA Mapping Service

We have years of experience in SNP array based genotyping of individuals for association studies and pharmacogenetics. Our GeneChip® Mapping Array service enable scientists to conduct large-scale linkage analysis, association, and copy number studies at a greater throughput and at a lower cost per data point. These high-density arrays contain thousands of single nucleotide polymorphisms (SNPs).

GeneChip® Mapping Arrays can be applied to a broad spectrum of genetic analyses:

• Linkage analysis
• Association studies
• LOH
• Chromosomal copy number analysis

We offer the range of Affymetrix GeneChip® Mapping arrays that cover 10,000 to 1 Million SNP´s in humans and many other species.

The full Affymetrix GeneChip Expression array processing service consists of RNA sample QC, cDNA and cRNA synthesis and QC, fragmentation, hybridisation and scanning. We use all currently available GeneChip expression arrays.

• Human GeneChip Arrays
  Human Genome U133 Set, Human Genome U133 Plus Array, Human Genome Focus Array, Human Genome U133 2.0 Array
  

• Rat GeneChip Arrays
  Rat Expression Set 230, Rat Genome 230 2.0 Array, Rat Genome U34 Set, Rat Neurobiology U34 Array, Rat Toxicology U34 Array
  

• Mouse GeneChip Arrays
  Mouse Expression Set 430, Mouse Genome 430 2.0 Array, Mouse Genome 430A 2.0 Array, Murine Genome U74v2 Set
  

• Other GeneChip Arrays
  Arabidopsis ATH1 Array, Bovine Genome Array, Canine Genome Array, C. elegans Genome Array, Chicken Genome Array, Citrus Genome Array, Drosophila Genome 2.0 Array, Drosophila Genome Array, E. coli Antisense Genome Array, E. coli Genome 2.0 Array, Maize Genome Array, Medicago Genome Array, P. aeruginosa Genome Array, Plasmodium/Anopheles Genome Array, Poplar Genome Array, Rhesus Macaque Genome Array, Rice Genome Array, Soybean Genome Array, Sugar Cane Genome Array, Test3 Array, Vitis vinifera (Grape) Genome Array, Wheat Genome Array, Xenopus laevis Genome Array, Yeast Genome 2.0 Array, Yeast Genome S98 Array, Zebrafish Genome Array.

Agilent Microarray Services

Agilent has leveraged its 60-mer technology to build catalog microarrays that will offer new levels of consistency, quality and performance compared to in-lab spotted arrays or traditional commercial oligo microarrays.

Bio-Rad Bio-Plex

The Bio-Plex system is a flexible, easy-to-use multiplex analysis system that permits the simultaneous analysis of up to 100 different biomolecules (proteins, peptides, or nucleic acids) in a single microplate well.

cDNA arrays

• Helicobacter pylori expression cDNA array (V1.0)
  The probes on this microarray representing 1632 ORF from HP including 1590 ORFs from strain 26695 and 103 from strain J99. All the probes were amplified from plasmid clones whose sequence was guaranteed by sequencing.
  

• Human 16K expression cDNA array (V2.3)
  The array represents 16450 verified human sequences from the NCBI RefSeq database, including 12581 known genes and 3869 ESTs. All the probes were amplified from plasmid clones whose sequence was guaranteed by sequencing. These genes can be categorized into cell division, cell signaling, cell structure, gene and protein expression, metabolism etc.

  Applications:

  1. Clarifying diseases.

  2. Validating drug targets.

  3. Discovering genes and characterizing gene function;

  4. Analyzing toxicological responses

  Features:

  1. High sensitivity and specificity;

  2. To facilitate data analysis, the genes in the array is fully annotated, which provides valuable information on molecular function and biological process.

  3. 16 quality control including 6 negative controls and 10 positive controls was used to assure the reliability of the result; Each control has been repeated for 48 times 4.the plasmid clone can be provided if further gene functional study is needed.
     

• Human 5K expression cDNA array (V1.0)
  The probes on this microarray were from NCBI RefSeq database. all 5075 genes are well studied and reviewed. All the probes were amplified from plasmid clones whose sequences were guaranteed by sequencing. This microarray is an ideal tool for researchers with limited resources and those just getting started with Microarray technology.

  Applications:

  1. Clarifying diseases

  2. Validating drug targets

  3. Discovering genes and characterizing gene function

  4. Analyzing toxicological responses

  Features:

  1. High sensitivity and specificity

  2. To facilitate data analysis, the genes in the array is fully annotated. which provides valuable information on molecular function and biological process

  3. 16 quality control including 6 negative controls and 10 positive controls was used to assure the result reliability;Each control has been repeated for 48 times 4.the plasmid clone can be provided if further gene functional study is needed
     
     

• Rat 12K expression cDNA array (V1.3)
  The array represents 11060 verified Rat sequences from the NCBI RefSeq database, including 5657 known genes and 4716 ESTs. All the probes were amplified from plasmid clones whose sequence was guaranteed by sequencing. These genes can be categorized into cell division, cell signaling, cell structure, gene and protein expression, metabolism etc.

  Applications:

  1. Clarifying diseases

  2. Validating drug targets

  3. Discovering genes and characterizing gene function

  4. Analyzing toxicological responses

  Features:

  1. High sensitivity and specificity

  2. To facilitate data analysis, the genes in the array is fully annotated. which provides valuable information on molecular function and biological process

  3. 16 quality control including 6 negative controls and 10 positive controls was used to assure the result reliability;Each control has been repeated for 48 times 4.the plasmid clone can be provided if further gene functional study is needed
     

• Rat receptor & ion channel cDNA microarry (V1.1)
  The probes on this microarray representing 418 rat receptor and ion channel genes. All the probes were amplified from plasmid clones whose sequence were guaranteed by sequencing. Rat receptor & ion channel cDNA microarry are designed to determine the expression profile of genes that encode for growth factor receptor, IFN receptor, hormone receptor, cytokine receptor, protein kinase, protein phosphatase, G protein, orphan protein, nuclear receptor; ion channel genes include voltage mediated ion channel, water channel, amino acid and nucleotide transfer protein, ion bump etc.
  

• Human Cell apoptotic cDNA array (V1.1)
  The array represents 458 apoptosis related genes. All the probes were amplified from plasmid clones whose sequence was guaranteed by sequencing. Human Cell apoptotic arrays are designed to determine the expression profile of genes that encode key ligands, receptors, intracellular modulators, and transcription factors involved in the regulation of programmed cell death. Other apoptosis-related arrays represent key signal transduction pathways and stress responses that initiate or propagate programmed cell death.

microRNA microarray

• Human microRNA oligo microarray(V1.0)
  Human microRNA oligo microarray is high quality microarray that contain probes targeting a comprehensive selection of human from miRBase (Sanger miRNA Registry). The 40bp probes on this microarray representing 307 human microRNA sequences.

  Features:

  1. Detect differential miRNA expression across tissues and among different disease states

  2. Highly reproducible results, superior sensitivity and specificity
     
     

• Mouse microRNA oligonucleotide array(V1.0)
  Mouse microRNA oligo microarrays are high quality microarrays that contain probes targeting a comprehensive selection of Mouse from miRBase (Sanger miRNA Registry). The 40bp probes on this microarray representing 223 mouse microRNA sequences.

  Features:

  1. Detect differential miRNA expression across tissues and among different disease states.

  2. Highly reproducible results, superior sensitivity and specificity.
     
     

• Rat microRNA oligonucleotide arrays (V1.0)
  Rat microRNA oligo microarrays are high quality microarrays that contain probes targeting a comprehensive selection of Mouse from miRBase (Sanger miRNA Registry). The 40bp probes on this microarray representing 172 Rat microRNA sequence.

  Features:

  1. Detect differential miRNA expression across tissues and among different disease states

  2. Highly reproducible results, superior sensitivity and specificity.

Protein Service

Our protein Services combine years of experience in custom protein production service with its leadership in cutting-edge technologies. This strategic pooling of talent, expertise and technologies presents an unprecedented opportunity for you to accelerate and upgrade your research. Our experts employ sophisticated, proprietary techniques to express, purify, and characterize proteins that match your exact needs:

• Cloning

• Subcloning

• cDNA cloning

• Point mutation

• Optimization of the expression conditions

• Conventional protein refolding

• His-tag Affinity purification
• SDS-PAGE and Western blot analysis

Tissue Arrays

The tissue array constitutes a new powerful tool for studies in post-genomic and post-proteomic validation. This newly developed technology provides a method of high-throughput molecular profiling and parallel analysis of biological and molecular characteristics for hundreds of pathologically controlled tissue specimens.

Tissue array technology is one of the company's main areas of expertise. We provide the highest quality tissue arrays which are manufactured under standardized conditions from recently procured tissues.

Application:

1. Discover various molecular events or molecules

2. Find candidates for novel molecular targets such as a cancer gene

3. Validate candidates for novel molecular targets using human tissues with appropriate information

Specialty CRO

We offer a full spectrum of biological discovery resources and expertise to meet the needs of the global pharmaceutical and biotech industries. Our broad range of services is designed to increase the speed, precision and productivity of your drug discovery and development activities.

Illumina gene expression profiling service

Illumina's gene expression profiling services in our R&D facility provides added value for your gene expression projects. Our scientific professionals work with you to understand your experimental objectives and then utilize BeadChip, DASL Assay to meet your project needs.

Illumina arrays interrogate multiple whole genomes or focused sets of target genes across large sample populations with low cost per sample.

• full-length 50-mer probes provide better selectivity and sensitivity

• high feature density enables low sample and reagent volumes

• feature redundancy (30X average) delivers high-confidence results

• low per-sample pricing allows bigger experimental scale

Illumina Genotyping Service

Illumina Genotyping consists of the following two features:

1.GoldenGate™ Assay SNP Genotyping
96 samples/plate
384, 768, 1152, 1536 SNPs/assay
99.94% call rate
99.99% reproducibility
0.005% non-Mendelian inheritance error rate
0.03% unlikely recombinant error rate

2.Whole Genome SNP Genotyping (WGG)
Unlimited multiplexing, no less than ~10K SNPs/assay
99.5% call rate
99.99% reproducibility

Mouse drug target expression oligonucleotide array (V1.0)

The probes on this microarray represent 438 drug target genes. These 70bp probes were all from Operon Company and located near 3' end. The sequence was derived from Unigene, mouse refseq database. Each 70mer probe is designed to have optimal specificity for its target gene and is melting-temperature normalized.

Features:

1. Highly sensitive-comparable to cDNA probes without the drawbacks of PCR amplification

2. Excellent specificity-sequence optimized to minimize cross-hybridization, allowing analysis of overlapping and homologous genes

3. Normalized hybridization conditions-melting-temperature (Tm) normalized oligo sets

4. Eukaryotic probes biased toward the 3' end of each gene.

Antibody service

Our custom polyclonal antibody development team provides multiple options to quickly meet your unique needs. For production of high quality antisera, we will match your choice of antigen (peptide, protein, biologic, or small molecule), to one of our tailored protocols, a preferred species, and production scale. Meticulous purification and characterization ensure the identity and performance of your order. Project status and data reports are monitored by our exclusive in-house custom service database tracking system. Our service is performed in clean room suites using standard operating procedures (SOPs) and can be recorded in GLP compliant batch records that are turned over to our clients upon completion of each production batch.

Bioinformatics Service

In collaboration with research, clinical laboratories in our R&D facility, the Bioinformatics Department has developed a complementary suite of software solutions and data analysis services to enable higher quality information to be extracted from high throughput data, while dramatically improving process automation and reducing costs.

In our bioinformatics department, qualified mathematicians, engineers, chemists biologists, and cytogeneticists who together deliver the highest quality commercial software and consumables, informed data analysis and responsive customer service.